Granulomatosis with Polyangiitis

Granulomatosis with Polyangiitis

Granulomatosis with Polyangiitis (GPA) is a rare autoimmune disease in which blood vessels and other tissues become inflamed

Granulomatosis with Polyangiitis (GPA) (formerly called Wegener’s Granulomatosis) is a rare autoimmune disease in which blood vessels and other tissues become inflamed. This inflammation limits blood flow to important organs in the body, potentially leading to long-term damage. Disease onset and severity varies between patients, and earlier diagnosis and treatment can prevent life-threatening organ failure. Although the disease can involve any organ system, GPA mainly affects the respiratory tract (sinuses, nose, trachea [windpipe], and lungs) and kidneys. This disorder can affect people at any age and strikes men and women equally. Compared to other racial groups, Caucasians are more commonly affected. The most common sign of GPA is upper respiratory tract distress such as sinus pain, discolored or bloody fluid from the nose, and nasal ulcers. A common sign of the disease is almost constant rhinorrhea (“runny nose”) or other cold symptoms that do not respond to usual treatment or become increasingly worse.

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Patricia Barber
Patricia Barber
For the last 20 years, Pat has been helping patients and caregivers live better lives, advocate for change, and Virginia's "right hand" making sure the "i's" are dotted and the "t's" are crossed. She lives in Michigan and couldn't picture herself doing anything but helping the autoimmune community.

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